File:Lomustine.jpg
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Lomustine
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Summary
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| Description |
English: Fig. 1Chemical structure and major mode of action of the nitrosourea lomustine (adapted from [2, 3]). A. Chemical structure of lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea). B-D. Mechanism of DNA crosslinking. Chlorethylation of guanine at the O6 site generates O6-chloroethylguanine by the active metabolite diazohydroxide (B). Intramolecular rearrangement of O6-chloroethylguanine to N1-O6-ethenoguanine (C). Formation of a N1-guanine-N3-cytosine interstrand crosslink (D). Carbamoylation of lysine or arginine residues and thus inactivation of proteins via the active metabolite isocyanate (E). |
| Date | |
| Source | https://pubmed.ncbi.nlm.nih.gov/32408220/ |
| Author | Michael Weller , Emilie Le Rhun |
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| current | 23:09, 4 January 2024 | | 670 × 779 (46 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Michael Weller , Emilie Le Rhun from https://pubmed.ncbi.nlm.nih.gov/32408220/ with UploadWizard |
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