File:Lysine demethylation.svg
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DescriptionLysine demethylation.svg |
English: Mechanisms of lysine demethylation by Lysine specific demethylase 1 (LSD1, also known as Lysine demethylase 1A, KDM1A) and by JmjC-domain-containing histone demethylases (JHDMs).
LSD1 first desaturates (oxidizes) the methylated lysine to an imine which is subsequently hydrolyzed to an amine and formaldehyde. LSD1 can only demethylate mono- and dimethylated lysines because trimethylated lysines miss a nitrogen-bound hydrogen (highlighted in green) that could be abstracted to form the imine. The mechanism of imine hydrolysis corresponds to an Alkylimino-de-oxo-bisubstitution in reverse.
LSD1 demethylates H3K4 and H3K9.
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Source | Own work |
Author | Hbf878 |
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http://creativecommons.org/publicdomain/zero/1.0/deed.enCC0Creative Commons Zero, Public Domain Dedicationfalsefalse |
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