File:MirrorImagePhageDisplay.png
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DescriptionMirrorImagePhageDisplay.png |
English: This image will appear in the wikipedia peptidomimetics page. Figure 3. Mirror image phage display. (A) A target L-amino acid protein (L-protein) for which an L-peptide inhibitor might be available is selected. The D-enantiomer protein (D-protein) is chemically synthesized from the same sequence using D-amino acids. If the target L-protein does not require a chaperone or co-factor to fold, the D-protein will mirror the conformation and properties of the L-protein, but the L-peptide inhibitor will most likely have little binding affinity towards it. (B) The synthesized D-proteins are fixed to a surface and exposed to phage displaying many different L-peptides. (C) L-peptides that do not bind well to the surface are washed away. The remaining L-peptides are sequenced. (D) The D-enantiomer peptides (D-peptides) of the binding L-peptides are synthesized using the same sequence and tested against the L-proteins. The D-peptide will bind the L-protein but most likely not bind the D-protein mirror. |
Source | Own work |
Author | Pablo.gainza |
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Public domainPublic domainfalsefalse |
I, the copyright holder of this work, release this work into the public domain. This applies worldwide. In some countries this may not be legally possible; if so: I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. |
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current | 07:00, 26 May 2010 | 1,775 × 691 (150 KB) | Pablo.gainza (talk | contribs) | {{Information |Description={{en|1=This image will appear in the wikipedia peptidomimetics page. Figure 3. Mirror image phage display. (A) A target L-amino acid protein (L-protein) for which an L-peptide inhibitor might be available is selected. The D-ena |
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