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File:Morphological change and somatic cell differentiation during the sex determination period, from the bipotential gonadal primordium at E10.5 to the differentiated testis at E12.5.png

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Figure 1. Schematic representation showing morphological change and somatic cell differentiation during the sex determination period, from the bipotential gonadal primordium at E10.5 to the differentiated testis at E12.5.
(A) At E10.5, the gonadal primordium appears as a long and narrow structure composed of the coelomic epithelium (CE) and the migrated CE cells (somatic cell precursors). CE cells express GATA4/WT1/SF1, and their ingression and asymmetric cell division are primarily controlled by Notch signaling with the NUMB distribution (magenta) and Notch signaling. PGCs migration occurs around E10.5.
(B) By E11.5, the gonadal primordium expands along the dorsoventral axis via the ingression of CE cells. Testis-specific Sry expression occurs in a center-to-pole manner along the anteroposterior axis. Beneath the CE, supporting cell precursors, SRY single- (cyan nuclei), SRY/SOX9 double- (blue nuclei), and SOX9 single- (deep-blue nuclei) positive cells, are distributed from the CE (dorsal)-to-mesonephric (ventral) side. SOX9-positive Sertoli cells secrete FGF9 and PGD2, and these factors upregulate and maintain Sox9 expression in the own and neighboring supporting cell precursors.

(C) At E12.5, testis cords are formed by Sertoli cells and germ cells (GCs). SOX9-positive Sertoli cells secrete paracrine factors, such as AMH and DHH. DHH signaling activates its downstream factor, GLI1, in fetal Leydig cell progenitors. Fetal Leydig cells with activated GLI1 (deep-green nuclei) produce androgens, which are converted to testosterone by Sertoli cells and then induce proper differentiation of the internal and external genital tract.
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Source https://www.researchgate.net/publication/365064403_Gonadal_Sex_Differentiation_and_Ovarian_Organogenesis_along_the_Cortical-Medullary_Axis_in_Mammals Gonadal Sex Differentiation and Ovarian Organogenesis along the Cortical–Medullary Axis in Mammals. Int. J. Mol. Sci. 2022,23, 13373. https://doi.org/10.3390/ijms232113373
Author Imaimatsu, K.; Uchida, A.; Hiramatsu, R.; Kanai, Y.
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.

Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Description Figure 2. Sertoli-Leydig cell tumor with cords and Leydig cell nests (A, HE stain) with a profile GATA-4 positive (B) and FOG-2 positive: thick arrow, Leydig cells FOG-2 negative; thin arrow, Sertoli cells FOG-2 positive (C).
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Source https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045914 GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype: Results from the TREP Project. PLoS ONE 7(9): e45914. https://doi.org/10.1371/journal.pone.0045914
Author Virgone C, Cecchetto G, Ferrari A, Bisogno G, Donofrio V, Boldrini R, et al.
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.

© Virgone et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Licensing

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w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

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current00:24, 5 July 2024Thumbnail for version as of 00:24, 5 July 20243,522 × 3,474 (2.06 MB)Rasbak (talk | contribs)
00:16, 5 July 2024Thumbnail for version as of 00:16, 5 July 2024550 × 543 (327 KB)Rasbak (talk | contribs){{Information |description= Figure 1. Schematic representation showing morphological change and somatic cell differentiation during the sex determination period, from the bipotential gonadal primordium at E10.5 to the differentiated testis at E12.5.<br> (A) At E10.5, the gonadal primordium appears as a long and narrow structure composed of the coelomic epithelium (CE) and the migrated CE cells (somatic cell precursors). CE cells express GATA4/WT1/SF1, and their ingression and asymmetric cell...

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