File:Negative allosteric modulator agonist plot.svg
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editDescriptionNegative allosteric modulator agonist plot.svg |
English: Negative allosteric modulator agonists (NAM-agonists) move agonist dose-response curves to higher agonist concentrations by decreasing agonist affinity and/or decrease maximal response by decreasing agonist efficacy. NAM-agonists also produce their own agonistic effects.
Plot shows receptor response (%) as a function of logarithmic agonist concentration ([Ago]). This is just an example and the units of concentration do not matter. Solid curve: original agonist response. Dashed curves: 2 possible response curves (out of many alternatives) after NAM-agonist addition. Arrows show approximate direction of the shift of curves after addition. Adapted from:
See also:
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Source | Own work |
Author | 5-HT2AR |
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http://creativecommons.org/publicdomain/zero/1.0/deed.enCC0Creative Commons Zero, Public Domain Dedicationfalsefalse |
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