File:Nrm2503-f2.jpg
Nrm2503-f2.jpg (655 × 440 pixels, file size: 118 KB, MIME type: image/jpeg)
File information
Structured data
Captions
Summary edit
DescriptionNrm2503-f2.jpg |
English: a | A network of three genes is modelled using ordinary differential equations (ODEs). Reaction rate constants are denoted by 'k'. b | The regulatory relations are depicted graphically. c | The trajectories of the model. Each equation shows the change in the level of a gene as a difference of its synthesis and degradation. Gene 1 is constitutively expressed, and is repressed by gene 3. Therefore, its level may reach a maximal rate of increase (k1,s; 's' stands for synthesis) when the level of gene 3 is 0, in which case k1,s will be multiplied by 1. When the level of gene 3 is non-zero, the level of gene 1 rises slower than k1,s. Transcription of gene 2 is activated by gene 1. This is expressed in the second equation of panel a, in which gene 2 level rises as a Michaelis–Menten function of the level of gene 1. Similarly, transcription of gene 3 is activated when both gene 1 and gene 2 levels are non-zero, and this relationship is given in the third equation of panel a. Degradation is modelled as a first-order reaction with rate constants ki,d (in which 'i' can be 1, 2 or 3). This formulation assumes that every transcript is immediately translated, and therefore the synthesis constants ki,s refer to both transcription and translation. According to simulation (bottom), the system stabilizes in a steady state at about 4.5 time units. The values of the rates in the simulations were: k1,s=k2,s=2; k3,s=15; k1,d=k2,d=k3,d=1; k2,1=k3,1=k3,2=1; and k1,3=100. The initial levels were all zero. Equations were solved using DESSolver v1.7 and the fourth order Runge–Kutta method. |
Date | |
Source | http://www.nature.com/nrm/journal/v9/n10/fig_tab/nrm2503_F2.html |
Author | Guy Karlebach & Ron Shamir |
Licensing edit
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 16:46, 25 June 2016 | 655 × 440 (118 KB) | Danaezarf (talk | contribs) | User created page with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on el.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Orientation | Normal |
---|---|
Horizontal resolution | 125 dpi |
Vertical resolution | 125 dpi |
Software used | Adobe Photoshop 7.0 |
File change date and time | 12:28, 11 September 2008 |
Color space | sRGB |