File:Nuclear integrity and genome stability in normal and HGPS cells.jpg
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English: Nuclear integrity and genome stability in normal and HGPS cells. In normal cells, DNA damage arises from exposure to environmental fctors including reactive oxygen species, radiation or chemicals. This damage can be readily repaired by the DNA repair machinery. On the other hand, the incorporation of Progerin (brown lines) in the nuclear lamin network (green lines) alters nuclear morphology, resulting in defective nuclear processes for the maintenance of telomere length and DNA damage responses. In Progerin-expressing cells, accelerated aging ensues. Chi et al. Journal of Biomedical Science 2009 16:96 doi:10.1186/1423-0127-16-96 Русский: Целостность оболочки ядра в нормальных (слева) клетках и клетках при прогерии (синдром Гетчинсона (Хатчинсона)-Гилфорда). |
| Source | The nuclear envelopathies and human diseases |
| Author | Ya-Hui Chi , Zi-Jie Chen and Kuan-Teh Jeang |
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© 2009 Chi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 20:36, 31 December 2009 | | 600 × 723 (64 KB) | CopperKettle (talk | contribs) | {{Information |Description={{en|1=Nuclear envelope breakdown and reassembly in mitosis. At the end of G2, the activation of cyclin-dependent kinases, including CDK1, triggers entry into mitotic prophase. The nuclear membrane breaks down, and the NE-associ |
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