File:Positive allosteric modulator antagonist plot.svg
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Summary
editDescriptionPositive allosteric modulator antagonist plot.svg |
English: Positive allosteric modulator antagonists (PAM-antagonists) move agonist dose-response curves to lower agonist concentrations by increasing agonist affinity, but decrease maximal response by decreasing agonist efficacy via their antagonist capability.
Plot shows receptor response (%) as a function of logarithmic agonist concentration ([Ago]). This is just an example and the units of concentration do not matter. Solid curve: original agonist response. Dashed curves: 2 possible response curves (out of many alternatives) after PAM-antagonist addition. Arrows show approximate direction of the shift of curves after addition. Adapted from:
See also:
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Date | |
Source | Own work |
Author | 5-HT2AR |
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editThis file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication. | |
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http://creativecommons.org/publicdomain/zero/1.0/deed.enCC0Creative Commons Zero, Public Domain Dedicationfalsefalse |
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