File:Progesterone levels after a single oral dose of 200 mg progesterone with food in postmenopausal women.png
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DescriptionProgesterone levels after a single oral dose of 200 mg progesterone with food in postmenopausal women.png |
English: Mean plasma corrected levels of progesterone after a single oral dose of 200 mg progesterone with food in postmenopausal women. Progesterone was formulated as a combination of 2 mg micronized estradiol and 200 mg micronized progesterone solubilized in medium-chain fatty acid oils derived from coconut oil and contained in single gelatin capsules (TX-001HR, by TherapeuticsMD). Food was a high-fat, high-calorie breakfast, with the medication taken 30 minutes later. Progesterone levels were determined using high-performance liquid chromatography (HPLC)–tandem mass spectrometry (TMS). Prometrium (micronized progesterone in peanut oil-filled capsules) was assessed as well under the same conditions and was found to have similar progesterone pharmacokinetics relative to the TX-001HR preparation.
Although not depicted in the graph, the Cmax for progesterone determined in the study was 89.2 ng/mL. Source of the values:
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Source | Own work |
Author | Medgirl131 |
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