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File:Progesterone levels measured via LC–MS–MS with 200 mg per day oral progesterone or 80 mg per day topical progesterone in postmenopausal women.png

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English: Levels of progesterone at steady state (day 12) in whole blood measured using liquid chromatography–tandem mass spectrometry (LC–MS/MS) during continuous therapy with 200 mg/day oral progesterone (one 200 mg capsule once daily) or 80 mg/day topical progesterone (one 40 mg Pro-Gest® over-the-counter cream application twice daily) in postmenopausal women.

Cmax levels were 2.8 ng/mL and Cavg(0–24) levels were 0.14 ± 0.18 ng/mL for oral progesterone. Median AUC levels were 12.5 ng•hour/mL for oral progesterone and 10.5 ng•hour/mL for topical progesterone.

Source of the values:

  • (June 2005). "Over-the-counter progesterone cream produces significant drug exposure compared to a food and drug administration-approved oral progesterone product". J Clin Pharmacol 45 (6): 614–9. DOI:10.1177/0091270005276621. PMID 15901742.
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Author Medgirl131

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