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File:R-loop factors rus.png

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Русский: Негативная суперскрученность ДНК способствует образованию R-петли. Топоизомеразы ингибируют образование R-петли, ослабляя отрицательную суперскрученность.

Наличие разрыва в вымещенной цепи ДНК цепи ниже промотора снижает эффективность восстановления структуры двунитевой ДНК, что способствует формированию R-петли. Вторичные структуры ДНК (например, G-квадруплексы, которые образуются на вымещенной цепи ДНК) также могут стабилизировать структуры R-петли. Серии из G-нуклеотидов в транскрипте РНК способствуют образованию R-петли.

Дефекты РНКазы H и РНК-ДНК-хеликаз, также повышают вероятность образования R-петли.
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Author Abogomazova

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