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English: A One goal would be the regeneration of thymic epithelium by direct differentiation of ES cells into cortical and medullary thymic progenitors which express graft antigens through the action of autoimmune regulator (AIRE) for re-educating the adult immune system. B Another goal would be to aim for “Hematopoietic mixed chimerism” using a mixture of both donor ES cell-derived and recipient hematopoietic stem cells (HSC) which then generate thymic dendritic cells (DC) capable of clonal deletion of donor- and auto-reactive T cells.
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StemBook Figure 1 Reprogramming the immune system using ES cells.

  • Lui, K.O., Fairchild, P.J., and Waldmann, H., Prospects for ensuring acceptance of ES cell-derived tissues (September 30, 2010), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.54.1, http://www.stembook.org.
Author Lui, K.O., Fairchild, P.J., and Waldmann, H., Prospects for ensuring acceptance of ES cell-derived tissues (September 30, 2010), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.54.1, http://www.stembook.org.
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