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Summary

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Description
English: Retroviral Replication Prior Integration
Key
  • Retrovirus positive sense RNA genome (black)
  • tRNA primer (black)
  • negative sense DNA strand (blue)
  • and positive sense DNA strand (red).
Events
  • A tRNA primer binding at PBS (Primer Binding Site)
  • B Initiation of negative sense DNA strand polymerisation
  • C RNAse H-catalysed degradation of the retroviral RNA genome upstream of the PBS.
  • D Negative sense DNA strand migration to and binding to the 3' terminus of the RNA by base-pairing at the R (Repeat) sequence.
  • E Elongation polymerisation of the negative sense DNA strand.
  • F RNAse H-catalysed degradation of the retroviral RNA genome downstream of the PPT (Polypurine Tract).
  • G Initiation of positive sense DNA strand polymerisation.
  • H RNAse H-catalysed degradation of the retroviral RNA genome upstream of the positive sense DNA strand and dissociation of the tRNA primer.
  • I Circularization of RNA-DNA hybrid duplex upon PBS base-pairing.
  • J Continued polymerisation of the positive sense DNA strand using the negative sense DNA strand as a template.
  • K Completed polymerisation of the positive sense DNA strand upon displacement the 5' end of the positive sense DNA strand.
  • L Completed polymerisation of the negative sense DNA strand using the positive sense DNA strand as a template.
  • M Mobile Provirus

All polymerisation reactions are catalysed by the enzyme reverse transcriptase.

Abbreviations
  • LTR = Long Terminal Repeat
  • PBS = Primer Binding Site
  • PPT = Polypurine Tract
  • R = Repeat Sequence
  • U3 = Unique 3' Sequence
  • U5 = Unique 5' Sequence
Date
Source Own work
Author Clevercapybara

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