File:Reverse Warburg effect.jpg
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| Description | Reverse Warburg effect. (In oncology, the Warburg effect (/ˈvɑːrbʊərɡ/) is the observation that most cancer cells release energy predominantly not through the 'usual' citric acid cycle and oxidative phosphorylation in the mitochondria as observed in normal cells, but through a less efficient process of 'anaerobic glycolysis' consisting of a high level of glucose uptake and glycolysis followed by lactic acid fermentation taking place in the cytosol, not the mitochondria, even in the presence of abundant oxygen) Cancer associated fibroblasts (CAFs) form spheroids with cancer cells shed into the peritoneal cavity, forming “Metastatic Units” (MU). Autophagy of fibroblasts provides cancer cells with nutrients and macromolecular building blocks. CAFs support energy metabolism of cancer cells by supplying them with lactate and amino acids. Aerobic glycolysis in cancer cells is more efficient (mitochondrial oxidation: 32 molecules ATP/molecule Glucose; aerobic glycolysis: 4 molecules ATP/molecule Glucose) than anaerobic glycolysis (2 molecules ATP/ molecule Glucose). MU facilitate resistance of cancer cells to anoikis |
| Date | |
| Source | https://www.researchgate.net/publication/331706360_Resistance_to_anoikis_in_transcoelomic_shedding_The_role_of_glycolytic_enzymes Resistance to anoikis in transcoelomic shedding: The role of glycolytic enzymes. Pleura and Peritoneum. 4. 10.1515/pp-2019-0003. |
| Author | Wilson, Robert & Solass, Wiebke & Archid, Rami & Weinreich, Jürgen & Königsrainer, Alfred & Reymond, Marc. |
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| current | 14:06, 3 June 2024 | | 850 × 582 (725 KB) | Rasbak (talk | contribs) | {{Information |description=Reverse Warburg effect. (In oncology, the Warburg effect (/ˈvɑːrbʊərɡ/) is the observation that most cancer cells release energy predominantly not through the 'usual' citric acid cycle and oxidative phosphorylation in the mitochondria as observed in normal cells, but through a less efficient process of 'anaerobic glycolysis' consisting of a high level of glucose uptake and glycolysis followed by lactic acid fermentation taking place in the cytosol, not the mitochond... |
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