File:Risks and 12-month burdens of incident postacute COVID-19 composite neurologic outcomes compared with the contemporary control cohort by care setting of the acute infection.webp
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Based on data about U.S. veterans; From study "Long-term neurologic outcomes of COVID-19"; it used the healthcare databases of the US Department of Veterans Affairs to build a cohort of 154,068 individuals with COVID-19 & 5.6 M contemporary controls
Summary
editDescriptionRisks and 12-month burdens of incident postacute COVID-19 composite neurologic outcomes compared with the contemporary control cohort by care setting of the acute infection.webp |
English: "Risks and burdens were assessed at 12 months in mutually exclusive groups comprising nonhospitalized individuals with COVID-19 (green), individuals hospitalized for COVID-19 (orange) and individuals admitted to intensive care for COVID-19 during the acute phase (first 30 days) of COVID-19 (purple). Composite outcomes consisted of cerebrovascular disorders (ischemic stroke, TIA, hemorrhagic stroke and cerebral venous thrombosis), cognition and memory disorders (memory problems and Alzheimer’s disease), disorders of the peripheral nerves (peripheral neuropathy, paresthesia, dysautonomia and Bell’s palsy), episodic disorders (migraine, epilepsy and seizures, and headache disorders), extrapyramidal and movement disorders (abnormal involuntary movements, tremor, Parkinson-like disease, dystonia, myoclonus), mental health disorders (major depressive disorders, stress and adjustment disorders, anxiety disorders, and psychotic disorders), musculoskeletal disorders (joint pain, myalgia and myopathy), sensory disorders (hearing abnormalities or tinnitus, vision abnormalities, loss of smell and loss of taste), other neurologic or related disorders (dizziness, somnolence, Guillain–Barré syndrome, encephalitis or encephalopathy and transverse myelitis) and any neurologic outcome (incident occurrence of any neurologic outcome studied). Outcomes were ascertained 30 days after the COVID-19-positive test until the end of follow up. The contemporary control cohort served as the referent category. Within the COVID-19 cohort were the nonhospitalized (n = 131,915), hospitalized (n = 16,764), those admitted to intensive care (n = 5,389) and contemporary control cohort (n = 5,606,761). Adjusted HRs (dots) and 95% (error bars) CIs are presented, as are estimated excess burdens (bars) and 95% CIs (error bars). Burdens are presented per 1,000 persons at 12 months of follow up. The dashed line marks a HR of 1.00; lower limits of 95% CIs with values greater than 1.00 indicate significantly increased risk." |
Date | |
Source | https://www.nature.com/articles/s41591-022-02001-z |
Author | Authors of the study: Evan Xu, Yan Xie & Ziyad Al-Aly |
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