The River Raisin is a river in southeastern Michigan, United States that flows through glacial sediments into Lake Erie. The area today is an agricultural and industrial center of Michigan. The river flows for almost 139 miles (224 km), draining an area of 1,072 square miles (2,780 km2) in the Michigan counties of Lenawee, Monroe, Washtenaw, Jackson, Hillsdale, a portion of Fulton County, Ohio, and Monroe County, where its mouth is located. French settlers named it as La Rivière aux Raisins because of the wild grapes growing along its banks, since the French word for grape is raisin. The French term for "raisin" is "raisin sec" (dry grape).

The River Raisin was used by local Potawatomi and Wyandot peoples, who used a portage between the upper river to gain access into the Grand and Kalamazoo rivers flowing west toward Lake Michigan. The river is still classified as canoeable throughout its length. But, low gradient, access issues, frequent logjams in the upper reaches and 22 dams on the mainstream limit its recreational use. The first European settlement of the river were the "ribbon" farms of Frenchtown established in the 1780s, which typically had narrow fronts on the river for access, with deep rectangular lots reaching back from the river. Now part of Monroe, Michigan, this area is still the most populous area along the river. The resort area of Irish Hills lies in the uppermost region of the watershed, which includes 429 lakes and ponds. The largest of these is the 800-acre (3.2 km2) Lake Columbia.

During the winter of 1813 as part of the War of 1812, the Battle of Frenchtown occurred near the river. British and Native American troops under the command of British General Henry Procter and Native American chiefs Roundhead, Walks in Water, and Split Log were allied against a division of ill-trained Kentucky infantry and militia under command of General James Winchester. Cut off and surrounded and facing total slaughter, Winchester surrendered with British assurances of safety of the prisoners. The British marched those who could walk to Detroit. But the next day, many of the severely wounded prisoners left in Frenchtown were killed by the Native Americans allies of the British.

The Massacre of the River Raisin became a rallying cry ("Remember the Raisin") particularly for Kentuckians. United States troops returned in the spring to drive the British from Michigan forever. The original battlefield was preserved for years as a county park in Monroe, Michigan and it has several monuments to the Kentucky soldiers who died there. On October 12, 2010, the land was transferred to the federal government. By Congressional authorization, it is now the only National Battlefield Park devoted to a battlefield of the War of 1812 - the River Raisin National Battlefield Park.

Since industrialization and intensified agriculture, the river has been polluted by industrial wastes and agricultural runoff. While cleanup efforts have mitigated some of the pollution, difficult-to-remove PCBs continue to constitute a hazardous waste. An established Area of Concern covers only 2 square miles (5.2 km2) of the watershed at the mouth of the river, much of which is industrial and harbor use, including the Ford Motor Company plant, Detroit Edison Monroe powerplant, and the Port of Monroe.

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