File:Schematic of different strategies to vascularization of brain organoid.webp
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DescriptionSchematic of different strategies to vascularization of brain organoid.webp |
English: A — Microinjection of brain organoids in mice brain led to engraftment and invasion by host vasculature. B — Co-culture of PSCs with endothelial cells; and C — genetic engineering of inducible transcription factor ETV2 in hESCs led to vascular system development in brain organoids. D — EBs early fed with endothelial factors such as VEGF and later with WNT7 display vascularization along with neuronal differentiation. E — Different fusion approaches led to brain organoid vascularization include fusion of (i) neural and mesodermal spheroid (ii) brain EB sandwiched with vascular EB in a Matrigel droplet (iii) brain EB and dissociated vascular organoids. |
Date | |
Source | https://www.nature.com/articles/s41420-023-01523-w |
Author | Yogita K. Adlakha |
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