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File:Specificity of immune responses against the malignant cancer-initiating cell depends on where antigen targets are expressed in the cell differentiation hierarchy..jpg

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English: In the example of CML, increased capacity for malignant self-renewal can arise from transformation of the hematopoietic stem cell (HSC) to give rise to chronic phase CML or from more differentiated progenitor cells, to give rise to blast crisis CML. Leukemic stem cell activity can result from impaired differentiation, increased cell survival, increased proliferation, increased genomic instability and/or increased self-renewal capacity. Examples of vaccination strategies are provided.
Date Published December 15, 2008.
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StemBook Figure 5 Specificity of immune responses against the malignant cancer-initiating cell depends on where antigen targets are expressed in the cell differentiation hierarchy.

  • Wu, C.J., Immunologic targeting of the cancer stem cell (December 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.21.1, http://www.stembook.org.
Author Wu, C.J., Immunologic targeting of the cancer stem cell (December 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.21.1, http://www.stembook.org.
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