File:Steps in nucleosome assembly.svg
Size of this PNG preview of this SVG file: 512 × 488 pixels. Other resolutions: 252 × 240 pixels | 504 × 480 pixels | 806 × 768 pixels | 1,074 × 1,024 pixels | 2,149 × 2,048 pixels.
Original file (SVG file, nominally 512 × 488 pixels, file size: 307 KB)
File information
Structured data
Captions
Summary edit
DescriptionSteps in nucleosome assembly.svg |
English: Nucleosome assembly begins with the binding of acetylated histone H3–H4 complexes to the assembly factor CAF-1. This complex is then recruited to the replication fork by an interaction with the sliding clamp, and a tetramer of histones H3 and H4 is loaded onto the nascent DNA to form half of a new nucleosome. Dimers of histones H2A and H2B are then loaded onto the DNA, probably with the assistance of other assembly factors such as NAP-1, to form the complete histone octamer. Chromatin-remodeling complexes contribute to nucleosome assembly and spacing. The number of histone H3 and H4 subunits that interact with CAF-1 is not clear. These subunits form highly stable tetramers in solution (unlike histones H2A and H2B, which form dimers) and it is therefore thought that CAF-1 loads a complete H3–H4 tetramer as shown here. There is some evidence, however, that CAF-1 can interact with an H3–H4 dimer, in which case the loading of a tetramer would require two CAF-1–histone complexes.[1] |
Date | |
Source | The Cell Cycle. Principles of Control. |
Author | David O Morgan |
Licensing edit
The copyright holder of this file allows anyone to use it for any purpose, provided that the copyright holder is properly attributed. Redistribution, derivative work, commercial use, and all other use is permitted. | |
Attribution |
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 18:03, 1 May 2020 | 512 × 488 (307 KB) | Rob Hurt (talk | contribs) | Uploaded a work by David O Morgan from The Cell Cycle. Principles of Control. with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on el.wikipedia.org
- Usage on en.wikipedia.org
- Usage on ja.wikipedia.org
- Usage on ms.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Width | 100% |
---|---|
Height | 100% |