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File:Structural differences between NPC1L1 and NPC1.png

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Structural differences between NPC1L1 and NPC1.


(A) In the closed form of NPC1L1(NTD), ASN211 forms a hydrogen bond with ASP208, allowing LEU213 to rotate toward α7. (B) In the cholesterol bound form of NPC1(NTD), ASN198 forms a hydrogen bond with the main chain amine of GLN200, which is rotated away from α7. (C) Superposition of NPC1L1(NTD) (yellow) and NPC1(NTD) (gray) within the cholesterol binding pocket. The smaller residues of NPC1L1, PHE35 and LEU216, expand the cholesterol binding pocket, accommodating sterols such as lanosterol.

doi:10.1371/journal.pone.0018722.g004
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Source http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018722
Author Hyock Joo Kwon, Maya Palnitkar, Johann Deisenhofer
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current03:48, 22 October 2013Thumbnail for version as of 03:48, 22 October 20136,859 × 2,154 (4.72 MB)Achim Raschka (talk | contribs){{Information |Description= Structural differences between NPC1L1 and NPC1. (A) In the closed form of NPC1L1(NTD), ASN211 forms a hydrogen bond with ASP208, allowing LEU213 to rotate toward α7. (B) In the cholesterol bound form of NPC1(NTD), ASN198 ...

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