File:The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers - A Meta-Analysis Based on 3,059,009 Subjects.pdf
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editDescriptionThe Relationship Between Plant-Based Diet and Risk of Digestive System Cancers - A Meta-Analysis Based on 3,059,009 Subjects.pdf |
English: Background and Objectives: Diets containing red or processed meat are associated with a growing risk of digestive system cancers. Whether a plant-based diet is protective against cancer needs a high level of statistical evidence.
Methods: We performed a meta-analysis of five English databases, including PubMed, Medline, Embase, Web of Science databases, and Scopus, on October 24, 2021 to identify published papers. Cohort studies or case-control studies that reported a relationship between plant-based diets and cancers of the digestive system were included. Summary effect-size estimates are expressed as Risk ratios (RRs) or Odds ratios (ORs) with 95% confidence intervals and were evaluated using random-effect models. The inconsistency index (I 2) and τ 2 (Tau 2) index were used to quantify the magnitude of heterogeneity derived from the random-effects Mantel-Haenszel model. Results: The same results were found in cohort (adjusted RR = 0.82, 95% CI: 0.78–0.86, P < 0.001, I 2 = 46.4%, Tau 2 = 0.017) and case-control (adjusted OR = 0.70, 95% CI: 0.64–0.77, P < 0.001, I 2 = 83.8%, Tau 2 = 0.160) studies. The overall analysis concluded that plant-based diets played a protective role in the risk of digestive system neoplasms. Subgroup analyses demonstrated that the plant-based diets reduced the risk of cancers, especially pancreatic (adjusted RR = 0.71, 95% CI: 0.59–0.86, P < 0.001, I 2 = 55.1%, Tau 2 = 0.028), colorectal (adjusted RR = 0.76, 95% CI: 0.69–0.83, P < 0.001, I 2 = 53.4%, Tau 2 = 0.023), rectal (adjusted RR = 0.84, 95% CI: 0.78–0.91, P < 0.001, I 2 = 1.6%, Tau 2 = 0.005) and colon (adjusted RR = 0.88, 95% CI: 0.82–0.95, P < 0.001, I 2 = 0.0%, Tau 2 = 0.000) cancers, in cohort studies. The correlation between vegan and other plant-based diets was compared using Z-tests, and the results showed no difference. Conclusions: Plant-based diets were protective against cancers of the digestive system, with no significant differences between different types of cancer. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322276, Identifier: CRD42022322276. |
Date | |
Source | https://www.frontiersin.org/articles/10.3389/fpubh.2022.892153/full |
Author | Yujie Zhao, Junyi Zhan, Yongsen Wang, and Dongli Wang |
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current | 22:13, 12 September 2022 | 1,239 × 1,622, 12 pages (12.51 MB) | Koavf (talk | contribs) | Uploaded a work by Yujie Zhao, Junyi Zhan, Yongsen Wang, and Dongli Wang from https://www.frontiersin.org/articles/10.3389/fpubh.2022.892153/full with UploadWizard |
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Author | Dongli Wang |
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Date and time of digitizing | 18:23, 30 May 2022 |
Software used | LaTeX with hyperref package + hypdvips |
File change date and time | 18:55, 30 May 2022 |
Date metadata was last modified | 18:55, 30 May 2022 |
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Conversion program | dvips + MiKTeX GPL Ghostscript 9.0 |
Encrypted | no |
Page size | 595.26 x 779.52 pts |
Version of PDF format | 1.6 |