File:Transferrin cycle.png
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Summary
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| Description | Binding of Transferrin. Transferrin (purple rhombus) binds two ferric iron atoms (orange squares) and circulates in the bloodstream until it comes into contact with transferrin receptors, which pair together to form dimers (red torpedo shapes) on the plasma membrane surface of cells. A complex of HFE (blue square) and β2-microglobulin (green square) binds to the transferrin receptor. Notably, the binding site for HFE overlaps the potential binding site of transferrin. Since it is likely that HFE associates with transferrin receptors shortly after synthesis, before the complex arrives at the plasma membrane, HFE can thus potentially prevent iron uptake through the transferrin receptor. Once transferrin binds the transferrin receptor (assuming that both potential binding sites are not blocked by HFE), the complex internalizes in an endosome, where acidification promotes release of ferric iron, and reduction by addition of an electron (e–) to ferrous or diferric iron allows transport of free iron from the endosome, using the divalent metal transporter, DMT1, to the cytosol. Upon release into the cytosol, iron can be incorporated into proteins, and its presence can be sensed by iron regulatory proteins (IRPs). |
| Date | Published: December 22, 2003 |
| Source | Rouault TA: How Mammals Acquire and Distribute Iron Needed for Oxygen-Based Metabolism. PLoS Biol 1/3/2003: e79. http://10.1371/journal.pbio.0000079 |
| Author | Rouault TA |
| Permission (Reusing this file) |
cc-by-2.5 |
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  This file is licensed under the Creative Commons Attribution 2.5 Generic license.
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 This file was published in a Public Library of Science journal. Their website states that the content of all PLOS journals is published under the Creative Commons Attribution 4.0 license (or its previous version depending on the publication date), unless indicated otherwise.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:06, 15 November 2006 | | 1,354 × 1,080 (573 KB) | Ayacop (talk | contribs) | {{Information |Description='''Binding of Transferrin.''' Transferrin (purple rhombus) binds two ferric iron atoms (orange squares) and circulates in the bloodstream until it comes into contact with transferrin receptors, which pair together to form dimers |
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