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File:Struttura dei glicani legati a SARS-CoV-2.jpg

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Italiano: I glicani rappresentativi sono modellati sulla struttura di prefusione della glicoproteina trimerica SARS-CoV-2 S (PDB ID 6VSB) ( 4 ), con un RBD nella conformazione "su" e gli altri due RBD nella conformazione "verso il basso". I glicani vengono colorati in base al contenuto di oligomannosio definito dalla legenda. I siti di legame del recettore ACE2 sono evidenziati in azzurro. Le subunità S1 e S2 sono renderizzate con una rappresentazione della superficie traslucida, rispettivamente di colore grigio chiaro e grigio scuro. Gli anelli flessibili su cui risiedono i siti glicanici N74 e N149 sono rappresentati come linee tratteggiate grigie, con i siti glicani sugli anelli mappati nelle rispettive regioni approssimative.
English: Representative glycans are modeled onto the prefusion structure of the trimeric SARS-CoV-2 S glycoprotein (PDB ID 6VSB) (4), with one RBD in the “up” conformation and the other two RBDs in the “down” conformation. The glycans are colored according to oligomannose content as defined by the key. ACE2 receptor binding sites are highlighted in light blue. The S1 and S2 subunits are rendered with translucent surface representation, colored light and dark gray, respectively. The flexible loops on which the N74 and N149 glycan sites reside are represented as gray dashed lines, with glycan sites on the loops mapped at their approximate regions.
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Source https://science.sciencemag.org/content/sci/369/6501/330/F3.large.jpg
Author Watanabe, Yasunori (2020-05-04). "Site-specific glycan analysis of the SARS-CoV-2 spike". Science (New York, N.Y.) 369 (6501): 330–333. American Association for the Advancement of Science (AAAS). DOI:10.1126/science.abb9983. PMID 32366695. PMC: 7199903. ISSN 0036-8075.

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Date/TimeThumbnailDimensionsUserComment
current13:54, 14 April 2021Thumbnail for version as of 13:54, 14 April 20211,280 × 704 (184 KB)OppidumNissenae (talk | contribs)Uploaded a work by {{cite journal | last=Watanabe | first=Yasunori | last2=Allen | first2=Joel D. | last3=Wrapp | first3=Daniel | last4=McLellan | first4=Jason S. | last5=Crispin | first5=Max | title=Site-specific glycan analysis of the SARS-CoV-2 spike | journal=Science (New York, N.Y.) | publisher=American Association for the Advancement of Science (AAAS) | volume=369 | issue=6501 | date=2020-05-04 | issn=0036-8075 | pmid=32366695 | pmc=7199903 | doi=10.1126/science.abb9983 | pages=330–333}...

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