File:A-MAPK-Driven-Feedback-Loop-Suppresses-Rac-Activity-to-Promote-RhoA-Driven-Cancer-Cell-Invasion-pcbi.1004909.s011.ogv
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English: FRET biosensors reporting Rac1 activity (top) or RhoA activity (bottom) for A2780 cells migrating over a 5 minute timecourse on 3D CDMs, stimulated with cRGDfV, treated with MEK1/2 inhibitor PD184352 and transfected with control siRNA (left) or Eps8 siRNA (right) to abrogate formation of the Sos1-Eps8-Abi1 complex. Thermal look up table applied as in Fig 4I–4L, where red denotes high GTPase activity and green denotes low GTPase activity. |
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| Source | S4 Movie from Hetmanski J, Zindy E, Schwartz J, Caswell P (2016). "A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1004909. PMID 27138333. PMC: 4854413. | ||
| Author | Hetmanski J, Zindy E, Schwartz J, Caswell P | ||
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  This file is licensed under the Creative Commons Attribution 4.0 International license.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 07:10, 18 October 2016 | 2.9 s, 1,024 × 1,024 (1.09 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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