File:A-MAPK-Driven-Feedback-Loop-Suppresses-Rac-Activity-to-Promote-RhoA-Driven-Cancer-Cell-Invasion-pcbi.1004909.s011.ogv
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editDescriptionA-MAPK-Driven-Feedback-Loop-Suppresses-Rac-Activity-to-Promote-RhoA-Driven-Cancer-Cell-Invasion-pcbi.1004909.s011.ogv |
English: FRET biosensors reporting Rac1 activity (top) or RhoA activity (bottom) for A2780 cells migrating over a 5 minute timecourse on 3D CDMs, stimulated with cRGDfV, treated with MEK1/2 inhibitor PD184352 and transfected with control siRNA (left) or Eps8 siRNA (right) to abrogate formation of the Sos1-Eps8-Abi1 complex. Thermal look up table applied as in Fig 4I–4L, where red denotes high GTPase activity and green denotes low GTPase activity. |
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Source | S4 Movie from Hetmanski J, Zindy E, Schwartz J, Caswell P (2016). "A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1004909. PMID 27138333. PMC: 4854413. | ||
Author | Hetmanski J, Zindy E, Schwartz J, Caswell P | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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current | 07:10, 18 October 2016 | 2.9 s, 1,024 × 1,024 (1.09 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | FRET biosensors reporting Rac1 activity (top) or RhoA activity (bottom) for A2780 cells migrating over a 5 minute timecourse on 3D CDMs, stimulated with cRGDfV, treated with MEK1/2 inhibitor PD184352 and transfected with control siRNA (left) or Eps8 siRNA (right) to abrogate formation of the Sos1-Eps8-Abi1 complex. |
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Author | Hetmanski J, Zindy E, Schwartz J, Caswell P |
Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Thermal look up table applied as in Fig 4I–4L, where red denotes high GTPase activity and green denotes low GTPase activity. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2016-05-03 |