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File:Activation-triggered-subunit-exchange-between-CaMKII-holoenzymes-facilitates-the-spread-of-kinase-elife01610v001.ogv

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English: Lateral opening in the hub domain. Video of a 1 μs molecular dynamics simulation of a vertical hub domain dimer that was extracted from the crystal structure of mouse CaMKIIα (PDB code: 1HKX). This simulation revealed transient fluctuations in the hub domain structure that opened the interface between helix αA and the underlying β sheet substantially. These fluctuations provide access to the hub cavity.

DOI:

https://dx.doi.org/10.7554/eLife.01610.023
Date
Source Video 1. from Stratton M, Lee I, Bhattacharyya M, Christensen S, Chao L, Schulman H, Groves J, Kuriyan J (2014). "Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity". eLife. DOI:10.7554/eLife.01610. PMID 24473075. PMC: 3901001.
Author Stratton M, Lee I, Bhattacharyya M, Christensen S, Chao L, Schulman H, Groves J, Kuriyan J
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current06:57, 23 March 201413 s, 1,280 × 720 (3.68 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 720P 1.57 Mbps Completed 17:48, 16 August 2018 19 s
Streaming 720p (VP9) 1.56 Mbps Completed 02:59, 25 January 2024 1.0 s
VP9 480P 771 kbps Completed 17:48, 16 August 2018 14 s
Streaming 480p (VP9) 768 kbps Completed 13:43, 17 December 2023 1.0 s
VP9 360P 474 kbps Completed 17:48, 16 August 2018 12 s
Streaming 360p (VP9) 471 kbps Completed 20:30, 18 December 2023 1.0 s
VP9 240P 270 kbps Completed 17:48, 16 August 2018 12 s
Streaming 240p (VP9) 267 kbps Completed 15:00, 9 December 2023 2.0 s
WebM 360P 502 kbps Completed 06:58, 23 March 2014 16 s
Streaming 144p (MJPEG) 485 kbps Completed 19:05, 29 October 2023 2.0 s
Stereo (Opus) 2 kbps Completed 21:23, 14 November 2023 1.0 s
Stereo (MP3) 129 kbps Completed 08:08, 29 October 2023 1.0 s

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