English: Cytosolic calcium in cells of an islet of Langerhans before, during, and after exposure to 12 mM glucose. LG1, ON, HG, OFF, and LG2 indicate the five different dynamical regimes considered in this study: low glucose prior to stimulation (LG1) – 0≤t<300, activation of beta-cells (ON) – 300≤t<420, sustained activity in high glucose (HG) – 600≤t<1000, deactivation of beta-cells (OFF) – 1080≤t<1200, and the low glucose after stimulation (LG2) – 1400≤t<1800. The red dot indicates the interval during which the cells were exposed to 12 mM glucose. During the time intervals before and after exposure to 12 mM glucose, cells were perifused with a solution containing 6 mM glucose.