File:Induced-Effects-of-Sodium-Ions-on-Dopaminergic-G-Protein-Coupled-Receptors-pcbi.1000884.s002.ogv
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Induced-Effects-of-Sodium-Ions-on-Dopaminergic-G-Protein-Coupled-Receptors-pcbi.1000884.s002.ogv (Ogg Theora video file, length 55 s, 537 × 546 pixels, 4.02 Mbps, file size: 26.19 MB)
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editDescriptionInduced-Effects-of-Sodium-Ions-on-Dopaminergic-G-Protein-Coupled-Receptors-pcbi.1000884.s002.ogv |
English: A 1.1 µs long-time MD simulation demonstrates that a sodium ion spontaneously penetrates the dopaminergic D2 receptor from the extracellular side. Once inside the receptor, the sodium ion provokes a conformational change of the rotamer switch Trp6.48. Moreover, in the presence of a sodium ion site c (below the rotamer switch Trp6.48), a second sodium ion is able to enter at times the D2 receptor where it occupies the orthosteric site a (above the rotamer switch Trp6.48). |
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Source | Video S1 from Selent J, Sanz F, Pastor M, De Fabritiis G (2010). "Induced Effects of Sodium Ions on Dopaminergic G-Protein Coupled Receptors". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1000884. PMID 20711351. PMC: 2920834. | ||
Author | Selent J, Sanz F, Pastor M, De Fabritiis G | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 00:24, 14 November 2012 | 55 s, 537 × 546 (26.19 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Selent J, Sanz F, Pastor M, De Fabritiis G |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
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Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2010-08 |