File:Major regulators of iron homeostasis.jpg
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editDescriptionMajor regulators of iron homeostasis.jpg |
English: (A) Hepcidin (hepcidin antimicrobial peptide) naturally limits the amount of iron efflux from cells and is inhibited by conditions such as anemia, hypoxia, increased testosterone, and increased erythropoiesis, while being upregulated by systemic iron overload and inflammation. (B) HIFs (hypoxia-inducible factor) respond to low oxygen and iron levels and transcribe genes to help cells adapt to perceived environmental deficiencies for a more sustainable metabolism and long-term survival; this results in short- and long-term changes including increases in glycolysis, angiogenesis, iron supplies, and ultimately cell vitality. (C) IRPs control gene translation through binding of IREs (iron response element) on mRNA transcripts for iron metabolism-related proteins, either promoting translation through 3' UTR binding-dependent stabilization (e.g., TFRC, SLC11A2), or inhibiting translation through 5' UTR binding that results in eventual degradation (e.g., ferritin complex, solute carrier family 40 member 1). |
Date | |
Source | “Targeting iron metabolism in cancer therapy”, in Theranostics (in en), volume 11, issue 17, (Please provide a date or year), DOI:10.7150/THNO.59092, ISSN 1838-7640, PMID 34373750, Wikidata Q110085617, pages 8412-8429 |
Author | Michael Morales and Xiang Xue |
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