English: HSV-2 shedding simulation with parameters derived from HIV negative study participants. The upper left panel represents total cell-free HSV DNA copies / mL present over time. The upper right panel represents spatial spread of cell-free virus during the episode. The lower left panel represents CD8+ T-cell density within each region. The lower right panel indicates reproductive number within each region. Quantities are displayed according to a heat map adjacent to each spatial map. The reproductive number (R) represents the growth potential of virus in a given region and is inversely correlated with CD+ T-cell density: values less than 1 (log 10 R = 0) are grey or black and indicate no potential for extended viral spread, while values exceeding 1 indicate potential for prolonged viral growth.