File:Microtubules-Depolymerization-Caused-by-the-CK1-Inhibitor-IC261-May-Be-Not-Mediated-by-CK1-Blockage-pone.0100090.s006.ogv
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editDescriptionMicrotubules-Depolymerization-Caused-by-the-CK1-Inhibitor-IC261-May-Be-Not-Mediated-by-CK1-Blockage-pone.0100090.s006.ogv |
English: Microtubule destabilizing effect of IC261 in interphase cells. CV-1 cells expressing EYFP-tubulin were cultured in a flow-through chamber, treated with DMSO (0.1%), 50 µM IC261 or 10 µM taxol +50 µM IC261 and observed by time-resolved fluorescence microscopy. Here exemplary cells are shown for time points “−29 min”, “0 min”, “10 min” und “30 min”. Treatment with IC261 induced the depolymerization of microtubules within a few minutes while in cells treated with 10 µM taxol 30 min prior to treatment with IC261 at time point “0 min” the IC261 microtubule destabilizing effect of IC261 could be blocked. |
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Source | Movie S2 from Stoter M, Kruger M, Banting G, Henne-Bruns D, Knippschild U (2014). "Microtubules Depolymerization Caused by the CK1 Inhibitor IC261 May Be Not Mediated by CK1 Blockage". PLOS ONE. DOI:10.1371/journal.pone.0100090. PMID 24937750. PMC: 4061085. | ||
Author | Stoter M, Kruger M, Banting G, Henne-Bruns D, Knippschild U | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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current | 21:56, 11 July 2014 | 8.6 s, 1,206 × 302 (3.44 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Stoter M, Kruger M, Banting G, Henne-Bruns D, Knippschild U |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Microtubule destabilizing effect of IC261 in interphase cells. CV-1 cells expressing EYFP-tubulin were cultured in a flow-through chamber, treated with DMSO (0.1%), 50 µM IC261 or 10 µM taxol +50 µM IC261 and observed by time-resolved fluorescence microscopy. Here exemplary cells are shown for time points “−29 min”, “0 min”, “10 min” und “30 min”. Treatment with IC261 induced the depolymerization of microtubules within a few minutes while in cells treated with 10 µM taxol 30 min prior to treatment with IC261 at time point “0 min” the IC261 microtubule destabilizing effect of IC261 could be blocked. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014 |