English: Microtubule destabilizing effect of IC261 in interphase cells. CV-1 cells expressing EYFP-tubulin were cultured in a flow-through chamber, treated with DMSO (0.1%), 50 µM IC261 or 10 µM taxol +50 µM IC261 and observed by time-resolved fluorescence microscopy. Here exemplary cells are shown for time points “−29 min”, “0 min”, “10 min” und “30 min”. Treatment with IC261 induced the depolymerization of microtubules within a few minutes while in cells treated with 10 µM taxol 30 min prior to treatment with IC261 at time point “0 min” the IC261 microtubule destabilizing effect of IC261 could be blocked.