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File:Single-Cell-Analysis-of-Drug-Distribution-by-Intravital-Imaging-pone.0060988.g005.jpg

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English: A. Representative images from a 5 hour PARP inhibitor pharmacokinetics assay. Far-Left Panel: drug distribution. Scale bar represents 50 µm. Middle-Left Panel: H2B Nuclear Marked tumor cells. Scale bar represents 50 µm. Middle-Right Panel: merged images displaying both the drug (green) and tumor cells (red). An area of the closest vessel was also selected to analyze the dynamics of drug distribution through the vasculature (Red box). Scale bar represents 50 µm. Far-Right Panel: Magnified cells from the presented image shown over time. The white arrow indicates a single cell visually tracked throughout the course of the video. Scale bar represents 10 µm. B. The average and standard deviation of nuclear drug concentration in all cells over time was analyzed using the described segmentation algorithm. The vessel concentration dynamics were also analyzed by quantifying drug channel fluorescence within an area of the vessel. C. The number of cells receiving a therapeutic dose of the drug over time.
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Source Image file from Giedt R, Koch P, Weissleder R (2013). "Single Cell Analysis of Drug Distribution by Intravital Imaging". PLOS ONE. DOI:10.1371/journal.pone.0060988. PMID 23593370. PMC: 3622689.
Author Giedt R, Koch P, Weissleder R
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current06:56, 8 May 2016Thumbnail for version as of 06:56, 8 May 2016678 × 536 (115 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.1371/journal.pone.0060988

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