File:Thymosin-β10-Expression-Driven-by-the-Human-TERT-Promoter-Induces-Ovarian-Cancer-Specific-Apoptosis-pone.0035399.s001.ogv
Thymosin-β10-Expression-Driven-by-the-Human-TERT-Promoter-Induces-Ovarian-Cancer-Specific-Apoptosis-pone.0035399.s001.ogv (Ogg Theora video file, length 26 s, 480 × 480 pixels, 1.48 Mbps, file size: 4.58 MB)
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editDescriptionThymosin-β10-Expression-Driven-by-the-Human-TERT-Promoter-Induces-Ovarian-Cancer-Specific-Apoptosis-pone.0035399.s001.ogv |
English: Ad.TERT.Tβ10-induced selective apoptotic morphological changes in human primary ovarian cancer cells, but not in normal fibroblasts. Co-cultured subconfluent primary human ovarian cancer cells and fibroblasts were exposed at 10 MOI of Ad.TERT.Tβ10, and morphological changes were observed at every 30 min using a real-time imaging system. White dotted circles are indicating selective morphological features of apoptosis, such as cell plasma membrane blebbing, cytoplasmic vacuolization, and cell shrinkage (after 10 hr), followed by loss of cell-to-cell interactions (after 15 hr). And black dotted circle tracking one of many fibroblasts indicates that they are not only alive but also actively moving for over 90 hrs. |
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Source | Movie S1 from Kim Y, Kim B, Lee J (2012). "Thymosin β10 Expression Driven by the Human TERT Promoter Induces Ovarian Cancer-Specific Apoptosis through ROS Production". PLOS ONE. DOI:10.1371/journal.pone.0035399. PMID 22623951. PMC: 3356296. | ||
Author | Kim Y, Kim B, Lee J | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 06:07, 18 November 2012 | 26 s, 480 × 480 (4.58 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Kim Y, Kim B, Lee J |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Ad.TERT.Tβ10-induced selective apoptotic morphological changes in human primary ovarian cancer cells, but not in normal fibroblasts. Co-cultured subconfluent primary human ovarian cancer cells and fibroblasts were exposed at 10 MOI of Ad.TERT.Tβ10, and morphological changes were observed at every 30 min using a real-time imaging system. White dotted circles are indicating selective morphological features of apoptosis, such as cell plasma membrane blebbing, cytoplasmic vacuolization, and cell shrinkage (after 10 hr), followed by loss of cell-to-cell interactions (after 15 hr). And black dotted circle tracking one of many fibroblasts indicates that they are not only alive but also actively moving for over 90 hrs. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2012 |