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Title: Ciba Foundation Symposium on the Regulation of Cell Metabolism
Identifier: cibafoundationsy1959ciba (find matches)
Year: 1959 (1950s)
Authors: Ciba Foundation Symposium on the Regulation of Cell Metabolism (1958 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-
Subjects: Cell metabolism
Publisher: Boston, Little, Brown
Contributing Library: MBLWHOI Library
Digitizing Sponsor: MBLWHOI Library

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Oxidative Pathways of Carbohydrate Metabolism 151 the biochemist. Until comparatively recently most discus- sions of this kind were concerned with the inter-relationships of the relative amounts of total carbohydrate, fat and protein metabolized, but now in addition it has become necessary to try to analyse the evidence indicating the preponderance of one metabolic pathway over another for one and the same GLUCOSE ATP;l G6P -HPO;^ FDP; DHArHGASP': dpn;adp\ PYRUVATE ' KREBS ^CYCLE LACTATE CO2+H2O DPNH
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GLYCOGEN UDPG \ 2DPN GLUCURONATE PentoseP^L-GULONATE ASCORBIC ACID REACTIONS GLYCOLYSIS & KREBS CYCLE G6P-OXIDATIVE &PENTOSE-P PATHWAYS URONATE PATHWAY Fig. 1. Pathways of glucose metabolism in animal tissues. Only essential intermediates are included in this diagram. major metabolite, and to try to discover those factors which determine which of the alternative pathways is that favoured by the cell under varying environmental conditions. Current views on probable metabolic pathways of carbo- hydrate metabolism in animal tissues are summarized in Fig.l. For detailed information on the development of knowledge of these routes, a number of recent reviews are available (Racker, 1954, 1957; Gunsalus, Horecker and Wood, 1955; Dickens, 1955, 19586; Horecker and Hiatt, 1958). Micro- organisms and plants which present in many cases an even

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