Identifier: physiologybioche00macl (find matches)
Title: Physiology and biochemistry in modern medicine
Year: 1918 (1910s)
Authors: Macleod, John James Rickard, 1876-1935 Pearce, R. G. (Roy Gentry), 1884-
Subjects: Physiology Biochemistry
Publisher: St. Louis : Mosby
Contributing Library: Columbia University Libraries
Digitizing Sponsor: Open Knowledge Commons

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Fi„ 197—Tracing showing the action of pituitrin on the uterine contractions and blood pressurein a dog. Made by Barbours method. (From Jackson.) eye is produced. The effect of pituitrin on the muscle of the bronchiolesis shown in Fig. 198. The glands on which the pituitrin has the most pronounced action are Till IlTIITAKY I.OHY 769 the mammary glands and the kidneys. Tht effect on the kidney is evi-denced by the remarkable increase in the urinary (low following injectionof the pituitrin. This diuresis might of course be due merely to thevasodilatation thai we have seen such extracts produce—a vasodilatationwhich is all the more marked because the vessels elsewhere in the bodyundergo constriction. But pituitrin continues to cause increased urinaryoutflow in the absence of any demonstrable vascular change; it also actsafter the administration of atropine, so that it is considered by mostobservers to act on the excretory epithelium of the convoluted tubules
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Fig. 198.—Tracing showing the constricting action of pituitrin on the bronchioles and its effecton blood pressure in a spinal dog. (From Jackson.) in much the same way as certain diuretics, like diuretin. This renalhormonic action of pituitrin would appear to be analogous with that ofsecretin on the epithelium of the pancreas. Another reason for believ-ing that the. secretory hormone is independent of that producing vaso-dilatation of the renal vessels is the fact that a repeated dose of pituitrin,although, as we have seen, it usually has a depressor action on the bloodvessels, still produces a stimulating effect on the excretion of urine.The value of pituitrin as a diuretic in clinical practice is now wellrecognized. The effect on milk secretion is best demonstrated by placing a cannula 770 THE ENDOCRINE ORGANS, OR DUCTLESS GLANDS in the mammary ducts so that the milk may freely flow out. By observ-ing the rate of outflow during the injection of pituitrin, it will be foundthat a re

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