Identifier: diseasesofinfa00kopl (find matches)
Title: The diseases of infancy and childhood
Year: 1910 (1910s)
Authors: Koplik, Henry, 1858- (from old catalog)
Subjects: Children
Publisher: New York and Philadelphia, Lea & Febiger
Contributing Library: The Library of Congress
Digitizing Sponsor: The Library of Congress

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ial connective tissue, withinflammatory changes in the smaller arteries. The liver in thesecases is not enlarged. In the cases presenting an enlarged liver thereis interacinous proliferation of connective tissue, beginning at theperiportal region and following the course of the bloodvessels. Thereis vasculitis, shown in a thickening of the adventitia of the blood-vessels. The parenchyma is degenerated. In other cases interacinouscollections of small round cells are on gross sections of the liver seenas yellow pinhead-sized spots. These are called by Hochsinger miliarygummata. Fully developed gummata of large size are very rare inthe liver of infants affected with hereditary syphilis. Spleen.—The spleen is in some cases enlarged to ten times itsnormal size. Gummata, single or multiple, occur, but are rare. Inhereditary syphilis not only is the parenchyma increased, but alsothe connective tissue of the spleen. Kidneys.—In rare cases there are induration and contraction of PLATE XXVI
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Congenital Syphilis. Showing nasal deformity.Newborn infant. SYPHILIS. 4~)\ the kidney. The parenchyma is retarded in development by intra-uterine syphilis and the connective tissue increased. Pancreas.—The pancreas may be enlarged and infiltrated, theparenchyma hard, and the interstitial connective tissue increased.There may be condylomatous ulcerations on the tongue, pharynx,and tonsil. Glandular Apparatus.—According to Hochsinger, the glandularapparatus of the gut may show a diffuse small-cell infiltration,Peyers patches may be infiltrated, and the vessels may be the seatof a vasculitis. The lymph-nodes are, as a rule, little changed exceptin cases with late manifestations. The thymus gland in cases ofhereditary syphilis has been found to be the seat of cystic degenera-tion (Eberle, Ribbert), caused by the dilated epithelial spaces of thefoetal thymus. Bone-changes.—The bone-changes in hereditary syphilis occurprincipally at that part of the bone between the epiphysis anddiap

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