Identifier: endocrineorgansi00shar (find matches)
Title: The endocrine organs; an introduction to the study of internal secretion
Year: 1916 (1910s)
Authors: Sharpey-Schäfer, E. A. (Edward Albert), Sir, 1850-1935
Subjects: Endocrinology Endocrine glands
Publisher: London, New York, Longmans, Green, and co.
Contributing Library: MBLWHOI Library
Digitizing Sponsor: MBLWHOI Library

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z have shown that in animals which undergoseasonal changes in sexual activity the interstitial cells may be even betterdeveloped when the seminiferous tubules are inactive than during the time 1 For a fuller discussion of the subject of internal secretion in connexion with the sexualorgans, F. H. A. Marshalls Physiology of Reproduction may be consulted. 132 The Interstitial Cells of the Testicle 133 of their activity, their increased development generally immediately pre-ceding that of the seminiferous epithelium. The tissue may also be foundwell developed in cases where there is atrophy of the contents of theseminiferous tubules, as in cases of cryptorchidism and after ligature of thevas deferens; although if the whole of the spermatic cord be included inthe ligature, so that the circulation and nerve-supply to the testicle is inter-fered with, the interstitial cells share in the general atrophy of the organwhich ensues, and the result is the same as castration (Vincent and Coleman).
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rap i FIG. 91.—Interstitial cells of testicle, human. Magnified 200 diameters. One tubuleand parts of two others are shown. The groups of interstitial cells lie in theloose intertubular reticular tissue. (Figs. 90 and 91 are from an iron-haematoxylinpreparation given me by Professor Martin Heidenhain.) These interstitial cells are polygonal in shape with spherical nucleus, awell-marked nucleolus, and a double centrosome. The cytoplasm oftencontains lipoid granules of a yellowish colour, which are blackened byosmic acid; besides other granules of protein nature, which may be eitheroxyphil or basiphil. Frequently there are crystals within the cells, butthe exact nature of these has not been determined. EFFECTS OF CASTRATION The results of removal of the testes are well known. If the operationis performed in the child the secondary sexual organs—especially theprostate and seminal vesicles—remain in an undeveloped condition, and thespecial secondary sexual characters, such as the gr

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