Identifier: materiamedicapha00bast (find matches)
Title: Materia medica : pharmacology, therapeutics and prescription writing for students and practitioners
Year: 1913 (1910s)
Authors: Bastedo, Walter Arthur, 1873-
Subjects: Pharmacology Therapeutics
Publisher: Philadelphia London : W.B. Saunders
Contributing Library: University of California Libraries
Digitizing Sponsor: Internet Archive

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no systemic effect, or almost none. Possiblyby constricting the arteries it prevents its own absorption. It isreported that an aqueous extract of two pounds of fresh supra-renal capsules has been swallowed without apparent ill effect.Osborne and some others claim that it is slowly absorbed fromthe mouth, though not from the stomach, while some have foundthat such large doses as % ounce (15 c.c.) of the 1 : 1000 epi-nephrine solution in the stomach have resulted in the character-istic effects on the circulation. A few cases also are reportedof marked systemic effects from its application to the conjunc-tiva, the nose, and the urethra. But, as a rule, no systemic effectat all is obtained from the drug when it is given by mouth or appliedto mucous membranes, and it seems to be rapidly destroyed atthe point of entrance into the tissues before it gets into thecirculation. 2. From subcutaneous injection there may be a slight rise inarterial pressure, but almost always there is no measurable
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EPINEPHRINE 189 effect. This is the authors experience in tests with studentsand asthmatics. There is, however, a fairly prompt effect uponcontracted bronchi, even though the arteries are unaffected. 3. From deep intramuscular injection enough seems to getinto the blood-stream to induce quite frequently a distinctthough comparatively small rise in arterial pressure and a re-laxation of the bronchi. These effects are most noticeable whenthe arteries are relaxed or the bronchi strongly contracted. 4. From intravenous administration there is an immediateand very marked rise in arterial pressure. This is the onlymethod of administration for a sure effect upon the arteries. Circulation.—The effect of an intravenous dose upon thecirculation is a marked rise in arterial pressure and a strengthenedand slowed heart. The rise in pressure is only momentary, butmay be maintained by repeating the dose or by continuous slowinfusion. A graduated rise in pressure may be obtained byintravenous injec

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