Identifier: endocrineorgansi00shar (find matches)
Title: The endocrine organs; an introduction to the study of internal secretion
Year: 1916 (1910s)
Authors: Sharpey-Schäfer, E. A. (Edward Albert), Sir, 1850-1935
Subjects: Endocrinology Endocrine glands
Publisher: London, New York, Longmans, Green, and co.
Contributing Library: MBLWHOI Library
Digitizing Sponsor: MBLWHOI Library

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. ^ D- O ^fe O So ..a co 3 £•£. o «so in the male this re-sult was not obtained.That corpora lutea arerelated to the develop-ment of the mammarygland during preg-nancy appears from theexperiments of Anceland Bouin and ofODonoghue, who havefound that if in thevirgin rabbit a Graatian O follicle be ruptured(even by mechanicalmeans) so that a corpusluteum develops, themammae undergo evo-lution ; whereas if acorpus luteum fails toform there is no suchevolution. Hammondand Marshall state thatunder these circum-stances the develop-ment of the mammaemay even proceed so faras to produce free se-cretion of milk. Ottand Scott have obtainedmarked development ofthe mammas, and evensecretion of milk, inyoung virgin rabbitsinjected subcutane-ously at frequent in-tervals for a monthwith extract of corpusluteum. It is further statedby Ancel and Bouinthat if all the corporalutea are destroyed ina pregnant rabbit thedevelopment of themammary gland is Metabolic Effects produced by Corpus Luteum 147
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I a B a a •a i •5 I § « .a o •8 3 s «s C .Q 0 a* S £ £ £ •«» o « S 03 u5. JS «•*- W) o S a ~S « •I 5g 3 •* 9< 3 •e2 o jS I ! CO tfi 2 ! 2 I py. ^) o3 148 The Endocrine Organs arrested, and it is inferred that their secretion is necessary for such develop-ment. It must, however, be pointed out that it is next to impossible todestroy the corpora lutea without practically destroying all the ovariantissue, for the corpora lutea of the pregnant rabbit form by far thegreater mass of the ovary. This applies also to Fraenkels experiments(see below). An important function of the internal secretion of the ovary—perhapsof the corpus luteum—relates to the formation of the uterine deciduaand the fixation of the embryo. Fraenkel—working upon a hypothesissuggested b) Born—found that if in rabbits the corpora lutea are destroyedat an early period of pregnancy the embryo does not become adherent tothe mucous membrane of the uterus, and ceases to develop. Marshall

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